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Postgraduate study programs


Supervisors: :

Prof. Soňa Nevšímalová, M.D., DSc.
Department of Neurology
Kateřinská 30, Praha 2, 128 21
Tel.: 224 96 55 62
E-mail: snevsi@lf1.cuni.cz

General PGS themes:
  • Disorders of sleep and wakfulness in childhood and adulthood (clinical polysomnographic, biochemical and genetic correlations
  • Exogenic factorc with impact on the quality of sleep (detection of changes in sleep macro- and microstructure). Civilisation diseases and quality of sleep.
  • Neurodevelopmental problems and neurometabolic disorders of childhood

Annotation of themes:
PGS research projects come out of the supervisor´s long-term study of the problems of sleep from the clinical, neurophysiological and genetic points of view. Research is centered both on primary disorders of sleep and waking but also on secondary sleep disorders concomitant to a number of neurological diseases. Research efforts are aimed also at the growing incidence of civilisation diseases related to disordered sleep quality and quantity. Other options for research projects are in the field of paediatric neurology - a spectrum of developmental, metabolic and degenerative diseases; projects orientated towards clinical, genetic and neurophysiological problems and also toward new diagnostic and therapeutic methods.

The supervisor´s three major theme-related publications:
1.Peyron C., Faraco J., Rogers W., Ripley B., Owereem S., Charnay Y., Nevsimalova S. et all: A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human marcoleptic brains. Nature Medicine 2000, 6: 991-997, IF 26.584
2.Nevšímalová S., Šonka K. (eds): Poruchy spánku a bdění , Galén, Praha 2007, 345 str.
3.Nevsimalova S. Narcolepsy in childhood. Sleep Medicine Review 2009, 13:169-180, IF 6.7

List of PGS graduates:
Graduate´s nameStart of PGSDissertation defenceName of dissertationNote
Jitka Vaňková, M.D., PhD.19982002Differential diagnosis of hypersomnias - a clinical, polysomnographic and genetic study contd. work on PhD thesis
Petr Bušek, M.D., Ph.D.19962004Some physiological and pathophysiological aspects of the autonomous nervous system 1996-2000 PS
2000-2004 KS
with a year´s pause
David Kemlink, M.D., PhD.20032006Genetic and aetiopathogenetic aspects of the restless leg syndrome 
Iva Příhodová, M.D., PhD.20032010Neurophysiological and imaging methods in children with disordered concentration and hyperactivity 
MUDr. Zdeněk Vojtěch, PhD.20062012Alternativní způsoby chirurgické léčby meziotemporální epilepsie

Current list of the supervisor´s PGS:
Student´s name Study duration and form Theme Note.
regular combined
Juraj Piško, M.D. 2010-   Diferenciální diagnostika hypersomnií: klinická, neurofyziologická, biochemická a genetická studie  
Michala Mosejová - Jakubíková, M.D. 2007-   Immunological, genetic and clinical aspects of myasthenia gravis  

List of salient publications produced within PG studies at the Department of Neurology:
1.Štěpánová I, Racek P, Havlová M, Nevšímalová S, Jakoubková M. Subakutní sklerotizující panencefalitida. Čes a Slov Neurol Neurochirurg 2002, 65/98:359-64, IF 0,047
2.Nevšímalová S, Havlová M, Tauberová A, Příhodová I. Alternující hemiplegie dětského věku. Cas Lek Cesk 2005; 144 (10): 692-6
3.Busek P, Vankova J, Opavsky J, Salinger J, Stepanova I, Nevsimalova S. Análisis espectral de la variabilidad del ritmo cardiaco y activatión cardíaca durante el despertar en el sonambulismo.Rev Neurol 2005; 41(6): 338-43, IF 0,391
4.Kemlink D, Polo O, Montagna P, Provini F, Stiasny-Kolster K, Oertel W, de Weerd A, Nevsimalova S, Sonka K, Högl B, Frauscher B, Poewe W, Trenkwalder C, Pramstaller PP, Ferini-Strambi L, Zucconi M, Konofal E, Arnulf I, Hadjigeorgiou GM, Happe S, Klein C, Hiller A, Lichtner P, Meitinger T, Müller-Myshok B, Winkelmann J. Family-based association study of the restless legs syndrome loci 2 and 3 in a European population.Movement Disord. 2007 Jan 15;22(2):207-12. Oceněno Českou společností pro výzkum spánku jako publikace roku pro autory do 35 let za rok 2007. IF 3,2
5.Kemlink D, Sonka K, Pretl M, Benakova H, Zima T, Nevsimalova S. Suggestive evidence of erythropoietin level abnormality in patients with sporadic and familial cases of the restless legs syndrome.Neuro Endocrinol Lett. 2007 Oct;28(5):643-6. IF 1,4
6.Winkelmann J, Polo O, Provini F, Nevsimalova S, Kemlink D, Sonka K, Högl B, Poewe W, Stiasny-Kolster K, Oertel W, de Weerd A, Strambi LF, Zucconi M, Pramstaller PP, Arnulf I, Trenkwalder C, Klein C, Hadjigeorgiou GM, Happe S, Rye D, Montagna P.Genetics of restless legs syndrome (RLS): State-of-the-art and future directions.Mov Disord. 2007;22 Suppl 18:S449-58. Review. Erratum in: Mov Disord. 2008 Jun;23(8):1200-2. IF 3,2
7.Kalina M, Liscak R, Vojtech Z, Adámková E, Procházka T, Marecková I, Vladyka V. Stereotactic amygdalohippocampectomy for temporal lobe epilepsy: promising results in 16 patients. Epileptic Disord. 2007 Dec;9. Suppl 1:S68-74. Impact Factor: 0,920
8.Kemlink D, Plazzi G, Vetrugno R, Provini F, Polo O, Stiasny-Kolster K, Oertel W, Nevsimalova S, Sonka K, Högl B, Frauscher B, Hadjigeorgiou GM, Pramstaller PP, Lichtner P, Meitinger T, Müller-Myshok B, Winkelmann J, Montagna P.Suggestive evidence for linkage for restless legs syndrome on chromosome 19p13.Neurogenetics. 2008 May;9(2):75-82. IF 4,2
9.Schormair B & Kemlink D, Roeske D, Eckstein G, Xiong L, Lichtner P, Ripke S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Högl B, Frauscher B, Gschliesser V, Poewe W, Peglau I, Vodicka P, Vávrová J, Sonka K, Nevsimalova S, Montplaisir J, Turecki G, Rouleau G, Gieger C, Illig T, Wichmann HE, Holsboer F, Müller-Myhsok B, Meitinger T, Winkelmann J.PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.Nat Genet. 2008 Aug;40(8):946-8 - IF 25,5
10.Kemlink D, Pretl M, Sonka K, Nevsimalova S.A comparison of polysomnographic and actigraphic evaluation of periodic limbmovements in sleep. Neurol Res. 2008 Apr;30(3):234-8. IF 1,6
11.Blazejova K., Illnerova H., Hajek I., Nevsimalova, S.: Circadian rhythm in salivary melatonin in narcoleptic patients. Neuroscience Let 2008, 437/2: 162-164. IF 2.092
12.Kemlink D, Polo O, Frauscher B, Gschliesser V, Högl B, Poewe W, Vodicka P, Vavrova J, Sonka K, Nevsimalova S, Schormair B, Lichtner P, Silander K, Peltonen L, Gieger C, Wichmann HE, Zimprich A, Roeske D, Müller-Myhsok B, Meitinger T, Winkelmann J. Replication of Restless Legs Syndrome Loci in Three European Populations. J Med Genet. 2009 Mar 10. 46(5):315-8 IF 5,5
13.Prihodova I, Sonka K, Kemlink D, Volna J, Nevsimalova S. Arousals in nocturnal groaning. Sleep Med 2009; 9:1051-55, IF 3,163
14.Vojtech Z, Vladyka V, Kalina M, Nespor E, Seltenreichová K, Semnická J, Liscák R. The use of radiosurgery for the treatment of mesial temporal lobe epilepsy and long-term results. Epilepsia. 2009 Sep;50(9):2061-71. Epub 2009 Mar 23. Impact Factor: 3.733
15.Malikova H, Vojtech Z, Liscak R, Prochazka T, Vymazal J, Vladyka V, Keller J, Kalina M. Stereotactic radiofrequency amygdalohippocampectomy for the treatment of mesial temporal lobe epilepsy: correlation of MRI with clinical seizure outcome. Epilepsy Res. 2009 Feb;83(2-3):235-42. Epub 2009 Jan 9. Impact Factor: 2.405
16.Prihodova I, Paclt I, Kemlink D, Skibova J, Ptacek R, Nevsimalova S. Sleep disorders and daytime sleepiness in children with attention-deficit/hyperactivity disorder: A two-night polysomnographic study with a multiple sleep latency test. In: Sleep Medicine, 2010, 11 (9): 922-928. IF 3.699
17.Jakubíková M. Kongenitální myastenické syndromy a myasthenie dětského věku. Neurologie pro praxi 2010; 11(2): 100-103
18.Jakubíková M., Seeman P. Kongenitální myastenické syndromy. In: Piťha J. a kol. Myasthenia gravis a ostatní poruchy nervosvalového přenosu. Praha: Maxdorf Jessenius; 2010. p. 319-41.
19.Liščák R, Maliková H, Kalina M, Vojtěch Z, Procházka T, Marusič P, Vladyka V. Stereotactic radiofrequency amygdalohippocampectomy in the treatment of mesial temporal lobe epilepsy. Acta Neurochir (Wien) 2010;152:1291-8. IF 1.329
20.Malíková H, Vojtěch Z, Liščák R, Procházka T, Vymazal J, Marečková I, Kalina M, Dbalý V, Keller J, Vladyka V. Microsurgical and stereotactic radiofrequency amygdalohippocampectomy for the treatment of mesial temporal lobe epilepsy: different volume reduction, similar clinical seizure control. Stereotact Funct Neurosurg 2010;88:42-50. IF 1.881
21.Malíková H, Liščák R, Vojtěch Z, Procházka T, Vymazal J, Vladyka V, Druga R. Stereotactic radiofrequency amygdalohippocampectomy: does reduction of entorhinal and perirhinal cortices influence good clinical seizure outcome? Epilepsia 2011;52:932-40. IF 3.961
22.Vojtěch Z, Krámská L, Malíková H, Seltenreichová K, Procházka T, Kalina M, Liščák R. Cognitive outcome after stereotactic amygdalohippocampectomy. Seizure 2012;21:327-33. IF 1.649
23.Malíková H, Krámská L, Liščák R, Vojtěch Z, Procházka T, Marečková I, Lukavský J, Druga R. Stereotactic radiofrequency amygdalohippocampectomy for the treatment of temporal lobe epilepsy: Do good neuropsychological and seizure outcomes correlate with hippocampal volume reduction? Epilepsy Res 2012 May 14. [Epub ahead of print] IF 2.302
24.Jakubíková M., Piha J., Latta J., Ehler E., Schutzner J. Myasthenia gravis, Castleman's disease, pemphigus and anti-phospholipid syndrome. Muscle and Nerve 2012, DOI: 10.1002/mus.23657<>, IF: 2,367
25.Adamovičová M., Fabriciová K., Jakubíková M., Příhodová I., Klement P., Sýkora P., Dusl M., Abicht A., Zeman J., Seeman P., Honzík T.?Kongenitální myastenie jako příčina respiračního selhání u dvou kojenců a batolete – kazuistiky. Cesk Slov Neurol N 2012,6:757-762, IF: 0,279
26.Bušková J, Vorlová T, Piško J, Sonka K. Severe sleep-related movement disorder induced by sertraline. Sleep Med. 2012, 13: 769-770, IF: 3.43
27.Nevsimalova S., Buskova J., Kemlink D., Pisko J., Prihodova I., Sonka K., Skibova J. Narcolepsy – clinical differences and sleep comorbidities in different age groups. J Neurol 2012, DOI: 10.1007/s00415-012-6702-4, IF: 3.853

Prof. Jan Roth M.D., PhD.
Department of Neurology
Kateřinská 30, Praha 2, 128 21
Tel.: 224 96 55 39
E-mail: jan1roth2@gmail.com

General PGS themes:
  • Clinical, functional and morphometric parameter correlations in Huntington´s disease
  • Non-motor manifestations of Huntington´s disease
  • Huntington´s disease: genetic testing impact on patients, persons at risk and caregivers

Annotation of themes:
PGS research projects based upon experience gathered at the Extrapyramidal Disease Centre with respect to the diagnostic, therapeutical and basic research problems related to Huntington´s disease. The Centre maintains close cooperation with the Institute of Medical Genetics, with the Department of Psychiatry and other institutions. The Center is part of the European Huntington´s Disease Network and takes a share in its activities. Available in the Centre´s database are the results of genetic tests, structured anamnestic data and results of auxiliary diagnostic methods including scales for the quantification of the patients´ motor and neuropsychological disorders. The database will help in the choidce of patients for further study cooperation. For clinical research purposes, use will also be made of specific MRI modalities, of neuropsychological testing by psychologists experienced in handling patients with Huntington´s disease, of speech therapists´ experience in the management of speech and swallowing disorders etc.

The supervisor´s major PGS theme-related publications:
1.Roth J., Radil T., Růžička E., Jech R., Tichý J.: Apomorphine does not influence olfactory thresholds in Parkinson´s Disease. Funct Neurol 1998,(13)2:99-103
2.Roth J., Havrdová E., Růžička E.: Atrophy of caudate nucleus in Huntington´s disease measured by means of computed tomography. J Neurol 2000,415:880-881
3.Roth J., Uhrová T., Doubek P., Preiss M., Židovská J., Havrdová E., Růžička E.: The impact of Huntington´s disease on caregivers. The Czech Experience. Revista Neuro-psiquiatría, Peru, 2002, Vol. 65, No. 3-4: 168-173
4.Roth J, Klempíř J, Jech R, Židovská J, Uhrová T, Doubek P, Ulmanová O, Brožová H, Volfová M, Serranová T, Růžička E. Caudate nucleus atrophy in Huntington's disease and its relationship with clinical and genetic parameters. Funct Neurol. 2005;20(3):127-130
5.Anders M, Uhrová T, Roth J. Depresivní stavy v neurologické praxi. Galén, 2005
6.Klempíř J, Špačková N, Nováková O, Židovská J, Roth J. Unified Huntington´s Disease Rating Scale: clinical practice and critical approach. Funct Neurol 2006;21(4):217-221
7.Roth J., Klempíř J, Špačková N. Neuropsychologie Huntingtonovy nemoci. In: Klinická neuropsychologie. M. Preiss, H.Kučerová eds., Grada 2006, s. 271-302
8.Jech R, Klempír J, Vymazal J, Zidovská J, Klempírová O, Růzicka E, Roth J. Variation of selective gray and white matter atrophy in Huntington's disease. Mov Disord. 2007 Sep 15;22(12):1783-9
9.Ruzicka E, Línková H, Penicka M, Ulmanová O, Nováková L, Roth J. Low incidence of restrictive valvulopathy in patients with Parkinson's disease on moderate dose of pergolide. J Neurol. 2007 Nov;254(11):1575-8
10.Vymazal J, Klempír J, Jech R, Zidovská J, Syka M, Ruzicka E, Roth J. MR relaxometry in Huntington's disease: Correlation between imaging, genetic and clinical parameters. J Neurol Sci. 2007 Dec 15;263(1-2):20-5
11.Židovská J., Klempíř J., Kebrdlová V., Uhrová T., Koblihová J., Anders M., Doubek P, Vevera J., Roth J. Huntingtonova nemoc: zkušenosti s genetickým testováním v letech 1994-2005. Čes a Slov. Neurol Neurochir. 2007,70/103 (1):72-77
12.Klempíř J, Roth J, Zárubová J, Písačka M, Špačková N, Tilley L. The McLeod syndrome: a case report. Parkinsonism and Related Disorders 2008, 14: 364-366
13.Havránková P, Jech, R, Roth J, Urgošík D, Růžička E. Beneficial effect of deep brain stimulation of Gpi in a patient with dystonia - deafness phenotype. Movement Disorders 2009, 24: 465-466
14.Klempíř J, Klempířová 0, Štochl J, Špačková N, Roth J. Relationship between impairment of voluntary movements and cognitive impairment in Huntington´s disease. J Neurol 2009, 256: 1629-1633
15.Štochl J, Hagtvet KA, Brožová H, Klempíř J, Roth J, Růžička E. Handedness does not predict side of onset of motor symptoms in Parkinson´s disease. Mov Disord 2009, 24 (12): 1836-1839
16.Klempíř J, Klempířová O, Roth J. Influence of emotional instability on behavioral disorders in DYT11. Mov Disord - in press
17.Brozova H, Stochl J, Roth J, Ruzicka E. Fear of Falling Has Greater Influence Than Other Aspects of Gait Disorders on Quality of Life in Patients with Parkinson's Disease. Neuro Endocrinol Lett. 2009;30(4):453-7
18.Fiala O, Pospisilova L, Prochazkova J, Matejckova M, Martasek P, Novakova L, Roth J, Ruzicka E. Parkin mutations and phenotypic features in Czech patients with early-onset Parkinson's disease. Neuro Endocrinol Lett. 2010 Apr 29;31(2):187-192.
19.Petr Dušek, Jitka Bušková, Evžen Růžička, Veronika Majerová, Antonín Srp, Robert Jech, Jan Roth, Karel Šonka. Effects of ropinirole prolonged-release on sleep disturbances and daytime sleepiness in Parkinson's disease. Clinical Neuropharmacology - in press
20.Záhoráková D, Ulmanová O, Kemlink D, Kofránková M, Roth J, Martásek P, Růžička E. No association with the ETM2 locus in Czech patients with familial essential tremor. Neuroendocrinol Letters, in press

List of PGS graduates:
Graduate´s nameStart of PGSDissertation defenceName of dissertationNote
Jiří Klempíř, M.D., Ph.D.20022007Huntington´s disease - an analysis of clinical, functional and morphometric parameters. 
Tereza Uhrová, M.D., Ph.D.20032011Psychosocial aspects of Huntington´s diseasespecialisation: medical psychology and psychopathology
Veronika Majerová, M.D., Ph.D.20082013Non-motor symptoms of basal gangia involvement. 

Current list of supervisor´s PG students:
Student´s name Study duration and form Theme Note.
regular combined
Petra Pelcová, M.D. 2009 -   Neuropsychiatric aspects of basal ganglia disorders  
Aleš Kopal, M.D.   2010 - Senzory and sensitive dysfunctions in neurodegenerative diseases within basal ganglia region  
Lucie Dvořáková, M.D. 2013 -   Pathophysiology of non-motor symptoms in neurodegenerative disorders
Mgr. Tomáš Nikolai 2010 -   Psychological aspects of dyskinetic syndromes specialisation: medical psychology and psychopatology

List of salient publications produced within PG studies at the Department of Neurology:
1.J.Klempíř, H. Hansíková, J. Roth, J. Židovská , M. Bohm a J. Zeman. Aktivity komplexů dýchacího řetězce v izolovaných trombocytech u 18 pacientů s Huntingtonovou nemocí. Čes a Slov. Neurol Neurochir., 2005, 3, 169-173
2.J. Klempíř, N. Špačková, O. Nováková, J. Židovská, J. Roth. Unified Huntington´s Disease Rating Scale: clinical practice and critical approach. Funct Neurol 2006, 21 (4): 217-221
3.Jech R, Klempír J, Vymazal J, Zidovská J, Klempírová O, Růzicka E, Roth J. Variation of selective gray and white matter atrophy in Huntington's disease. Mov Disord. 2007 Sep 15;22(12):1783-9
4.Vymazal J, Klempír J, Jech R, Zidovská J, Syka M, Ruzicka E, Roth J. MR relaxometry in Huntington's disease: Correlation between imaging, genetic and clinical parameters. J Neurol Sci. 2007 Dec 15;263(1-2):20-5
5.Židovská J., Klempíř J., Kebrdlová V., Uhrová T., Koblihová J., Anders M., Doubek P, Vevera J., Roth J. Huntingtonova nemoc: zkušenosti s genetickým testováním v letech 1994-2005. Čes a Slov. Neurol Neurochir. 2007,70/103 (1):72-77
6.Klempíř J, Nováková O, Roth J. Poruchy paměti a bazální ganglia. In: Paměť a její poruchy. J Hort, R. Rusina eds. Maxdorf 2007, 313-17
7.Klempíř J, Roth J, Zárubová J, Písačka M, Špačková N, Tilley L. The McLeod syndrome: a case report. Parkinsonism and Related Disorders 2008, 14: 364-366.
8.Klempíř J, Klempířová, Štochl J, Špačková N, Roth J. Relationship between impairment of voluntary movements and cognitive impairment in Huntington´s disease. J Neurol 2009, 256: 1629-1633

Prof. Evžen Růžička, M.D., DSc.
Department of Neurology
Kateřinská 30, Praha 2, 128 21
Tel.: 224 96 55 50
E-mail: eruzi@lf1.cuni.cz

General PGS themes:
  • Study of motor and non-motor effects of deep brain stimulation in extrapyramidal movement disorders
  • Analysis of gait and other inborn and acquired movement stereotypes and their disorders
  • Selection, phenotypic characteristics and gene analysis of clinical subpopulations of individuals with extrapyramidal diseases (essential tremor, juvenile Parkinson´s disease, Tourette syndrome and the like)
  • Neuropharmacological mechanisms and therapeutic studies in extrapyramidal movement disorders

Annotation of themes:
PGS research projects are inspired by the clinical work done by the Extrapyramidal Disease Centre. Hypo- and hyperkinetic movement disorders in Parkinson´s disease and other extrapyramidal affections serve as model examples for the study of movement control mechanisms in man. Clinimetric, functional-imaging, kinesiological, electrophysiological and neuropsychological methods are made use of for the monitoring of motor and non-motor manifestations of the disease. They are also applied for studying the effects of pharmacological and non-pharmacological therapeutic procedures (including functional neurosurgical operations and physiotherapeutical techniques). Clinical-epidemiological and genetic studies are undertaken for the purpose of learning more about the aetiopathogenesis of each of the pathological entities.

The latest major publications on PGS themes:
1.Růžička E, Hallett M, Jankovic J, eds. Gait Disorders. Philadelphia: Lippincott Williams & Wilkins, 2001: 403 s.
2.Růžička E., Roth J., Kaňovský P. et al.: Dyskinetické syndromy. Extrapyramidová onemocnění II. Galén Praha 2002:320 s.
3.Růžička E., Urgošík D., Jech R., Serranová T., Volfová M., Roth J. et al. Hluboká mozková stimulace v léčbě Parkinsonovy nemoci a třesu: Pražská zkušenost 1998-2003. Čes a Slov Neurol Neurochir 2004;67/100:423-436
4.Balash Y., Giladi N., Růžička E., Jankovic J.: Disorders of posture and gait. In: Jankovic J and Tolosa E, eds. Parkinson's disease and movement disorders, 5th Edition. Philadelphia: Lippincott Williams & Wilkins 2007
5.Růžička E, Línková H, Penicka M, Ulmanová O, Nováková L, Roth J. Low incidence of restrictive valvulopathy in patients with Parkinson's disease on moderate dose of pergolide. J Neurol 2007;254:1575-1578

List of PGS graduates:
Graduate´s nameStart of PGSDissertation defenceName of dissertationNote
Robert Jech, M.D., PhD.19932000New methods of evoked response analysis and synthesis: Basic principles and examples of clinical applications 
Kateřina Venderová, MSc., PhD19992003Herbal addictive substances: Cannabinoids and the CSN cannabinoid system in relation to some neurological diseasesCU Faculty of Pharmacology, co-supervision
Carl Nikolaus Homann, M.D., PhD.20012004The Bradykinesia Akinesia IncoordinationTest for measuring motor dysfunction in Parkinson´s disease 
Olga Ulmanová-Veselá, M.D., PhD.19992006Essential tremor as a model disease for the analysis of tremor 
Alena Zumrová, M.D., PhD20042007Spinocerebellar degeneration: Clinical studies and molecular diagnosis 
Hana Brožová, M.D., PhD20012009Postural and gait disorders in extrapyramidal diseases 

Current list of supervisor´s PG students:
Student´s name Study duration and form Theme Note.
regular combined
Lucie Nováková-Zelená, M.D. 2001-2005 2005- Non-motor effects of deep brain stimulation  
Tereza Serranová, M.D.   2003- Deep brain stimulation and extrapyramidal diseases - clinical and neurophysiological studies interrupted (matern. leave)
Ondřej Fiala, M.D. 2005-   Molecular pathology study of extrapyramidal movement disorders  
Ondřej Bezdíček, MSc. 2008-   Cognitive deficit structure in extrapyramidal diseases  
Martina Hoskovcová, M.D. 2008-   Disorders of balance and gait in extrapyramidal diseases  
Marie Kofránková, M.D. 2009-   Pathophysiological mechanisms of essential tremor  

List of salient publications produced within PG studies at the Department of Neurology:
1.Jech R., Růžička E.: Kognitivní a zrakové funkce ve stáří: Analýza evokovaných potenciálů. Čas Lék Čes 1995;134:791-797
2.Jech R., Růžička E.: Brain stem auditory evoked potentials reflect central nervous system involvement in myasthenia gravis. J Neurol 1996;243:547-557
3.Bohbot V.D., Jech R., Bureš J., Nadel L., Růžička E.: Spatial and non-spatial memory involvement in myasthenia gravis, J Neurol 1997;244:529-532
4.Jech R., Růžička E., Nebuželský A., Krásenský J., Obenberger J., Seidl Z.: Funkční magnetická resonance a evokované potenciály - základní principy a aplikace. Psychiatrie 1999;3:228-236
5.Veselá O, Růžička E., Jech R., Roth J., Štěpánková K., Mečíř P., Solano Z., Preclíková E.: Colour discrimination impairment is not a reliable early marker of Parkinson´s disease. J Neurol 2001;248:975-978
6. Venderová K., Růžička E., Višňovský P.: Effect of cannabis on Parkinson´s disease symptoms: questionnaire based study. Homeostasis 2001;41:140-142
7.Fiala O., Růžička E.: International database of Tourette syndrome: pilot study of the project in Czech Republic. Homeostasis 2001;41:146-151
8.Veselá O., Růžička E., Jech R., Roth J., Mečíř P., Volfová M.: Esenciální tremor v naší populaci nemocných - základní charakteristika onemocnění a vyšetření kresbou spirály. Čes a Slov Neurol Neurochir 2002;65/98:181-186
9.Venderová K., Višňovský P., Růžička E.: Potenciální využití kanabinoidů ve farmakoterapii. Slovenský lekár 2002;12/26:208-212
10.Homann CN, Quehenberger F, Petrovic K, Hartung HP, Ruzicka E, Homann B, Suppan K, Wenzel K, Ivanic G, Ott E. Influence of age, gender, education and dexterity on upper limb motor performance in Parkinsonian patients and healthy controls. J Neural Transm 2003;110:885-897
11.Fiala O., Růžička E.: Mezinárodní databáze Touretteova syndromu: zapojení do projektu v České Republice. Čes a Slov Neurol Neurochir 2003;66/99:197-202
12.Homann CN, Suppan K, Wenzel K, Homann B, Pluta-Furst A, Crevenna R, Schinagl D, Ruzicka E, Dressler D, Ivanic G. East-west differences in the organization of botulinum toxin use in nine Central European countries. Eur J Neurol 2003;10:213-219
13.Ulmanová O., Růžička E.: Diferenciální diagnóza třesu. Postgraduální medicína 2003;5:426-429
14.Homann DD, Suppan K, Homann B, Crevenna R, Ivanic G, Ruzicka E. Driving in Parkinson's disease-a health hazard? J Neurol 2003;250:1439-46
15.Venderová K, Růžička E, Vorisek V, Visnovsky P. Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptoms. Mov Disord. 2004;19:1102-6>
16.Roth J, Ulmanová O, Růžička E. Orgánové změny navozené ergotovými agonisty dopaminu: Čas na změnu léčebných doporučení u Parkinsonovy nemoci? Cas Lek Cesk 2005;144:123-6
17.Ulmanová O, Homann CN, Ulman R, Jech R, Čapek V, Klempíř J, Růžička E. Tremor magnitude: a single index to assess writing and drawing in essential tremor. Parkinsonism Rel Disord 2007;13:250-253
18.Novaková L, Růžička E, Jech R, Serranová T, Dušek P, Urgošík D. Increase in body weight is a non-motor side effect of deep brain stimulation of the subthalamic nucleus in Parkinson's disease. Neuro Endocrinol Lett. 2007;28:21-5
19.Stochl J, Boomsma A, van Duijn M, Brožová H, Růžička E. Mokken scale analysis of the UPDRS: dimensionality of the Motor Section revisited. Neuro Endocrinol Lett 2008;29:151-158
20.Stochl J, Boomsma A, Růžička E, Brožová H, Blahus P. On the structure of motor symptoms of Parkinson's disease. Mov Disord 2008;23:1307-1312
21.Valkovič P, Brožová H, Bötzel K, Růžička E, Benetin J. Push and release test predicts better Parkinson fallers and nonfallers than the pull test: comparison in OFF and ON medication states. Mov Disord 2008;23:1453-1457

Prof. Karel Šonka, M.D., DSc.
Department of Neurology
Kateřinská 30, Praha 2, 128 21
Tel.: 224 96 55 68 (18)
E-mail: ksonka@lf1.cuni.cz

General PSG themes:
  • Sleep-related breathing disorders
  • Sleep and waking disorders in neurological diseases
  • Pathophysiology of sleep and waking disorders
  • Social aspects of sleep and waking disorders

Annotation of themes:
The themes are based on the clinical experience gathered by staff members of the Centre for Sleep and Waking disorders of the VFN General Teaching Hospital and CU 1st Medical Faculty. Sleep-related breathing disorders are very frequent, occurring either alone or in combination with concomitant diseases. The rate of sleep disorders underlying neurological diseases is quite significant, which is why our own and foreign neurological centres worldwide devote a great deal of efforts to these inter-relations. Knowing more about them can help expand our knowledge of their pathophysiology as well as improve the patients´quality of life. Research at the Department of Neurology, CU 1st MF, benefits from a well equipped sleep laboratory, a large number of standardly examined patients, and from cooperation with related as well as remote disciplines. While the social aspects of sleep and, in particular, waking disorders are under intensive study worldwide, little attention has been paid to them in the CR so far. Hence, we regard this line of research as useful and prospective science-wise.

3 latest major publication on the theme:
1.Nevšímalová S, Šonka K (eds). Poruchy spánku a bdění. Galén, Praha, 2007:1-345
2.Sonka K, Kemlink D, Buskova J, Pretl M, Srutkova Z, Maurovich Horvat E, Vodicka P, Polakova V, Nevsimalova S. Obesity accompanies narcolepsy with cataplexy but not narcolepsy without cataplexy. Neuro Endocrinol Lett 2010;31(5): 631-634
3.Brabec J, Rulseh A, Horinek D, Pala A, Guerreiro H, Buskova J, Petrovicky P, Nemcova V, Krasensky J, Seidl Z, Nimsky C, Sonka K. Volume of the amygdala is reduced in patients with narcolepsy - a structural MRI study. Neuro Endocrinol Lett, 2011;32:652-656
4.Postuma RB, Montplaisir JY, Pelletier A, Dauvilliers Y, Oertel W, Iranzo A, Ferini-Strambi L, Arnulf I, Hogl B, Manni R, Miyamoto T, Mayer G, Stiasny-Kolster K, Puligheddu M, Ju Y, Jennum P, Sonka K, Santamaria J, Fantini ML, Zucconi M, Leu-Semenescu S, Frauscher B, Terzaghi M, Miyamoto M, Unger MM, Cochen De Cock V, Wolfson C. Environmental risk factors for REM sleep behavior disorder: A multicenter case-control study. Neurology. 2012;79:428-434

List of PGS graduates:
Graduate´s nameStart of PGSDissertation defenceName of dissertationNote
Vladimír Weiss, M.D., PhD.19962000Sleep apnoea syndrome in acromegaly  
Julius Šimko, M.D. PhD. 2007Carbamazepine medication and the risk of hypothyroidism 
Simona Dostálová, M.D., PhD. 2008Craniofacial abnormities in sleep apnoea syndrome 

Current list of supervisor´s PG students:
Student´s name Study duration and form Theme Note.
regular combined
Eszter Horvath Maurovich, M.D. 2005-2010 2010- Sleep deprivation  
Tereza Vorlová, M.D.   2007- Sleep apnoea and vestibular dysfunction  
Jana Slonková, M.D.   2008- Sleep-related breathing disorders in post-stroke patients  
MUDr. Petra Kovalská 2012-   Ventilační poruchy ve spánku (sleep-related breathing disorder- SRBD) u pacientů po akutním CMP  

List of salient publications produced within PG studies at the Department of Neurology:
1.Weiss V, Šonka K, Pretl M, Dostálová S, Klozar J, Rambousek P, Marek J, Haas T. Prevalence of the sleep apnea syndrome in acromegaly population. J Endocrinol Invest 2000;23:515-519
2.Dostálová S, Šonka K, Šmahel Z, Weiss V, Marek J, Hořínek D. Craniofacial abnormalities and their relevance for sleep apnoea syndrome aetiopathogenesis in acromegaly.Eur J Endocrinol 2001;144:491-497
3.Jakoubková M, Šonka K, Roth J, Růžička E, Michalčíková B, Jech R, Mečíř P, Nevšímalová S. Spánek při Parkinsonovy nemoci - dotazníkové šetření.Čes a Slov Neurol Neurochir 2001;64/97:268-272
4.Šonka K, Pretl M, Hnídková P, Nevšímalová S, Jakoubková M, Smolík P, Dauvilliers Y, Tafti M. Dvě kazuistiky rekurentní hypersomnie - klinika a polysomnografie. Čes a Slov Neurol Neurochir 2002;65/98:199-205
5.Dostálová S, Šonka K, Šmahel Z, Weiss V, Marek J. Cephalometric assessment of cranial abnormalities in patients with acromegaly.J CranioMaxilloFac Surg 2003;31:80-87
6.Kemlink D, Šonka K, Nevšímalová S, Pretl M, Benáková M, Zima T, Pantelakis L, Serranová T. Rodinné a sporadické formy syndromu neklidných nohou. Čes a Slov Neurol Neurochir 2003;66/99:387-391
7.Jakoubková M, Šonka K, Roth J, Růžička E, Jech R, Volfová M, Mečíř P, Nevšímalová S. Poruchy spánku u Parkinsonovy nemoci - subjektivní a objektivní údaje.Čes a Slov Neurol Neurochir 2003;66/99:392-394
8.Foltán R, Hoffmannová J, Donev F, Vlk M, Šonka K, Pretl M. Advancement musculus genioglossus a závěs jazylky v terapii obstrukčního spánkového apnoického syndromu. Čes a Slov Neurol Neurochir 2006;69/102:57-63
9. Šonka K, Kemlink D, Pretl M. Cataplexy treated with escitalopram - clinical experience. Neuro Endocrinol Lett. 2006;27(1-2):174-176
10.Kemlink D, Polo O, Montagna P, Provini F, Stiasny-Kolster K, Oertel W, de Weerd A, Nevsimalova S, Sonka K, Hogl B, Frauscher B, Poewe W, Trenkwalder C, Pramstaller PP, Ferini-Strambi L, Zucconi M, Konofal E, Arnulf I, Hadjigeorgiou GM, Happe S, Klein C, Hiller A, Lichtner P, Meitinger T, Muller-Myshok B, Winkelmann J. Family-based association study of the restless legs syndrome loci 2 and 3 in a European population. Mov Disord. 2007; 22 (2): 207-212
11. Vaňková Bušková J, Bušek P, Volná J, Šonka K, Nevšímalová S. Abnormal sleep microstructure and autonomic response in narcolepsy. Cesk Slov Neurol N 2007;70/103(2):158-162
12.Šonka K, Kelemen J, Kemlink D, Volná J, Pretl M, Zima T, Benákova H, Rambousek P, Foltán R, Donev F. Evening and morning plasma levels of protein S100B in patients with obstructive sleep apnea. Neuro Endocrinol Lett 2007;28(5):575-579
13.Kemlink D, Sonka K, Pretl M, Benakova H, Zima T, Nevšímalová S. Suggestive evidence of erythropoietin level abnormality in patients with sporadic and familial cases of the restless legs syndrome. Neuro Endocrinol Lett 2007;28:643-646
14.Šonka K, Pretl M, Havránková P, Volná J, Dušek P, Salvet A, Hening WA. Úspěšné použití jediné otázky pro screening syndromu neklidných nohou v České republice. Cesk Slov Neurol N 2007;70/103(6):685-686
15.Kemlink D, Pretl M, Šonka K, Nevšímalová S. A comparison of polysomnographic and actigraphic evaluation of periodic limb movements in sleep. Neurol Res 2008;30(3):234-238
16.Prihodova I, Sonka K, Kemlink D, Volna J, Nevsimalova S. Arousals in nocturnal groaning.Sleep Med. 2009;10:1051-1055
17.Nitsche MA, Jakoubkova M, Thirugnanasambandam N, Schmalfuss L, Hullemann S, Sonka K, Paulus W, Trenkwalder C, Happe S. Contribution of the premotor cortex to consolidation of motor sequence learning in humans during sleep. J Neurophysiol. 2010;104:2603-2614
18.Maurovich Horvat E, Tormášiová M, Slonková J, Kemlink D, Maurovich Horvat L, Pretl M, Nevšímalová S, Šonka K. Assessment of pregnancy outcomes in Czech and Slovak women with narcolepsy. Med Sci Monit 2010;16(12):SR35-40
19.Sonka K, Kemlink D, Buskova J, Pretl M, Srutkova Z, Maurovich Horvat E, Vodicka P, Polakova V, Nevsimalova S. Obesity accompanies narcolepsy with cataplexy but not narcolepsy without cataplexy. Neuro Endocrinol Lett 2010;31(5): 631-634
20.Volná J, Kemlink D, Kalousová M, Vávrová J, Majerová V, Mestek O, Švarcová J, Šonka K, Zima T. Biochemical oxidative stress related markers in patients with obstructive sleep apnea. Med Sci Monit 2011,22;17(9):CR491-497
21.Bušková J, Klempíř J, Majerová V, Picmausová J, Sonka K, Jech R, Roth J, Růžička E. Sleep disturbances in untreated Parkinson's disease. J Neurol 2011;258(12):2254-2259
22.Winkelmann J, Czamara D, Schormair B, Knauf F, Schulte EC, Trenkwalder C, Dauvilliers Y, Polo O, Högl B, Berger K, Fuhs A, Gross N, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Xiong L, Montplaisir J, Rouleau GA, Fietze I, Vávrová J, Kemlink D, Sonka K, Nevsimalova S, Lin SC, Wszolek Z, Vilarino-Güell C, Farrer MJ, Gschliesser V, Frauscher B, Falkenstetter T, Poewe W, Allen RP, Earley CJ, Ondo WG, Le WD, Spieler D, Kaffe M, Zimprich A, Kettunen J, Perola M, Silander K, Cournu-Rebeix I, Francavilla M, Fontenille C, Fontaine B, Vodicka P, Prokisch H, Lichtner P, Peppard P, Faraco J, Mignot E, Gieger C, Illig T, Wichmann HE, Müller-Myhsok B, Meitinger T. Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1. PLoS Genet 2011;7(7): 1-10, e1002171
23.Brabec J, Rulseh A, Horinek D, Pala A, Guerreiro H, Buskova J, Petrovicky P, Nemcova V, Krasensky J, Seidl Z, Nimsky C, Sonka K. Volume of the amygdala is reduced in patients with narcolepsy - a structural MRI study. Neuro Endocrinol Lett, 2011;32:652-656
24.Bušková J, Vorlová T, Piško J, Sonka K. Severe sleep-related movement disorder induced by sertraline. Sleep Med. 2012;13:769-770
25.Vávrová J, Kemlink D, Sonka K, Havrdová E, Horáková D, Pardini B, Müller-Myhsok B, Winkelmann J. Restless legs syndrome in Czech patients with multiple sclerosis: An epidemiological and genetic study. Sleep Med. 2012;13(7):848-51

Assoc. Prof. Eva Havrdová, M.D, PhD.
Department of Neurology
Kateřinská 30, Praha 2, 128 21
Tel.: 224 96 65 15
E-mail: ehavr@lf1.cuni.cz

General PGS themes:
  • Immunosuppressive methods in the treatment of multiple sclerosis including its malignant forms
  • Neurorehabilitation for motor function control in MS patients

Annotation of themes:
1.Tests for the safety and efficacy (clinical, immunological, MRI) of combination methods with immunosuppressives in MS management. Introduction of intensive immunoablation method in the treatment of malignant MS. Detection of patients responding to treatment or having risk factors for malignant prognosis with the aid of molecular - genetic methods in cooperation with KDDL laboratory and Prof. P.Martásek, DrSc.).
2.Monitoring the effect of modern neurorehabilitation methods in MS management (including functional MRI) - in cooperation with PhDr. K. Řasová, PhD.
3.Neuropsychology of MS
Note for anyone interested: priority is given to candidates who frequented the Centre for Demyelination Disorder already during the undergraduate studies and who participated both in clinical investigation and in scientific projects.

Supervisor´s major theme-related publications in the past 5 years:
1.Frohman EM, Stuve O, Havrdova E, et al. Therapeutic considerations for disease progression in multiple sclerosis: evidence, experience, and future expectations. Arch Neurol. 2005 Oct;62(10):1519-30
2.Havrdova E. Aggressive multiple sclerosis-is there a role for stem cell transplantation? J Neurol. 2005 Sep;252 Suppl 3:iii34-iii37
3.Rasova K, Brandejsky P, Havrdova E, Zalisova M, Rexova P. Spiroergometric and spirometric parameters in patients with multiple sclerosis: are there any links between these parameters and fatigue, depression, neurological impairment, disability, handicap and quality of life in multiple sclerosis? Mult Scler. 2005 Apr;11(2):213-21
4.Havrdova E. Aggressive multiple sclerosis-is there a role for stem cell transplantation? J Neurol. 2005 Sep;252 Suppl 3:iii34-iii37
5.Frohman EM, Stuve O, Havrdova E, Corboy J, Achiron A, Zivadinov R, Sorensen PS, Phillips JT, Weinshenker B, Hawker K, Hartung HP, Steinman L, Zamvil S, Cree BA, Hauser S, Weiner H, Racke MK, Filippi M. Therapeutic considerations for disease progression in multiple sclerosis: evidence, experience, and future expectations. Arch Neurol. 2005 Oct;62(10):1519-30
6.Fassas A, Passweg JR, Anagnostopoulos A,Kazis A, Kozak T, Havrdova E, Carreras E, Graus F, Kashyap A, Openshaw H, Schipperus M, Deconinck E, Mancardi G, Marmont A, Hansz J, Rabusin M, Zuazu Nagore FJ, Besalduch J, Dentamaro T, Fouillard L, Hertenstein B, La Nasa G, Musso M, Papineschi F, Rowe JM, Saccardi R, Steck A, Kappos L, Gratwohl A, Tyndall A for the Autoimmune Disease Working Party of the EBMT (European Group for Blood and Marrow Transplantation): Hematopoetic stem cell transplantation for multiple sclerosis: a retrospective study. J Neurol. 2002, vol 249, No 8, p. 1088-1097
7. Stepan JJ, Havrdova E, Tyblova M, Horakova D, Ticha V, Novakova I, Zikan V. Markers of bone remodeling predict rate of bone loss in multiple sclerosis patients treated with low dose glucocorticoids. Clin Chim Acta. 2004 Oct;348(1-2):147-5

List of PGS graduates:
Graduate´s nameStart of PGSDissertation defenceName of dissertationNote
Ondřej Doležal, M.D.20032009Neurorehabilitation effect assessment with fMRI in MS patients, CNS plasticity  
Hana Kalistová, M.D. 2003Immunological findings in the CSF of MS patients 
PhDr. Kamila Řasová20002004Scope for physiotherapy in MS management 
Eva Krasulová, M.D.20042013Cytokine production of peripheral lymphocytes and monocytes in MS patients in different stages of the disease and with regard to the therapeutic impact 

Current list of supervisor´s PG students:
Student´s name study duration and form Theme Note.
regular combined
Veronika Tichá, M.D.   2001- Multiple sclerosis - treatment with first-choice medication: beta interferon, glatimer acetate - and their combination with conventional immunosuppressives: effect and toleratbility study, beta interferon and pulse therapy comparison (effect vs. side effects and cost effectiveness of the two regimens)  
Michaela Týblová, M.D.   2000- Multiple sclerosis - neurophysiological functions and rate of physical exertion relative to immunological factors  
Hana Horáková, M.D.   2003- Predictive markers of clinical state development in MS patients  
Jana Dušánková, MSc.   2005- Neuropsychological problems of MS  
Ali Alatar, MSc.   2005- Functional movement disorders in MS  

List of salient publications produced within PGS at the Department of Neurology:
1.Zálišová K, Havrdová E: Vliv komplexního fyzioterapeutického programu (jehož součástí je aerobní zátěž) na fyzickou kondici, únavu a neurologický deficit nemocných s roztroušenou sklerózou mozkomíšní - pilotní studie. Č Slov Neurol. a Neurochir 2001,5:173-177
2.Řasová K. (Zálišová K), Havrdová E: Vliv komplexního fyzioterapeutického programu (jehož součástí je aerobní zátěž) na fyzickou kondici, únavu a neurologický deficit nemocných s roztroušenou sklerózou mozkomíšní - pilotní studie. Č Slov Neurol. a Neurochir 2001,5:173-177
3.Řasová K, Havrdová E, Brandejský P. Únava nemocných s roztroušenou sklerózou mozkomíšní. Klidový režim versus aerobní zatěžování. Čes a slov Neurol Neurochir 2002; 3: 145-149
4.Tichá V, Havrdová E, Nováková I, Horáková D: Mitoxantron v léčbě aktivní RS. Čes a slov Neurol Neurochir 66/99, 2003, No 1, 31-37
5.Rasova K, Brandejsky P, Havrdova E, Zalisova M, Rexova P. Spiroergometric and spirometric parameters in patients with multiple sclerosis: are there any links between these parameters and fatigue, depression, neurological impairment, disability, handicap and quality of life in multiple sclerosis? Mult Scler. 2005 Apr;11(2):213-21
6.Rasova K, Krasensky J, Havrdova E, Obenberger J, Seidel Z, Dolezal O, Rexova P, Zalisova M. Is it possible to actively and purposely make use of plasticity and adaptability in the neurorehabilitation treatment of multiple sclerosis patients? A pilot project. Clin Rehabil. 2005 Mar;19(2):170-81
7.Bušek P., Horáková D., Opavský J., Salinger J., Jech R., Šlachta R., Havrdová E. :Krátkodobá spektrální analýza variability srdeční frekvence u roztroušené sklerozy, Čes a Slov Neurol a Neuroch, 67/100, 2004; No 1: 37-42
8.Stepan JJ, Havrdova E, Tyblova M, Horakova D, Ticha V, Novakova I, Zikan V. Markers of bone remodeling predict rate of bone loss in multiple sclerosis patients treated with low dose glucocorticoids. Clin Chim Acta. 2004 Oct;348(1-2):147-54

Assoc. Prof. Robert Jech M.D., PhD.
Department of Neurology
Kateřinská 30, Praha 2, 128 21
Tel.: 224 96 55 39
E-mail: jech@cesnet.cz

General PGS themes:
  • Pathophysiological mechanisms of movement control in extrapyramidal diseases
  • Functional magnetic resonance - new tasks and their application in neurology and neurosurgery

Annotation of themes:
Research is centered on the effects of deep brain stimulation, on the analysis of the physiological mechanisms of voluntary movement control and on the pathophysiological mechanisms of abnormal motor patterns (dystonia, myoclonus, tremor, Parkinsonism), white matter MR tractography, multimodal evoked potentials, unit brain activity recording, electroencephalography and transcranial magnetic stimulation

The supervisor´s main theme-related publications:
1.Jech R., Bareš M., Křepelová A., Urgošík D., Havránková P., Růžička E. DYT 6 - a novel THAP1 mutation with excellent effect on pallidal DBS. Mov Disord 2011 (v tisku)
2.1. Urgošík D., Jech R., Růžička E. Hluboká mozková stimulace u nemocných s extrapyramidovými poruchami pohybu - stereotaktická procedura a intraoperační nálezy. Čes a Slov Neurol Neurochir 2011 (v tisku)
3.Adamovičová M, Jech R, Urgošík D, Špačková N, Křepelová A. Pallidal stimulation in siblings with pantothenate kinase-associated neurodegeneration - 4 year follow-up. Mov Disord 2010 (e-pub)
4.Timmermann L., Pauls K.A.M., Wieland K., Jech R., Kurlemann G., Sharma N., Gill S.S., Haenggeli C.A., Hayflick S.J., Hogarth P., Leenders K.L., Limousin P., Malanga C.J., Moro E., Ostrem J.L., Revilla F.J., Santens P., Schnitzler A., Tisch S., Valldeoriola F., Vesper J., Volkmann J., Woitalla D., Peker S. Dystonia in Neurodegeneration with Brain Iron Accumulation: outcome of bilateral pallidal stimulation. Brain. 2010; 133(Pt3):701-12
5.Jech R., Bareš M., Urgošík D., Černá O., Klement P., Adamovičová M., Příhodová I., Ošlejšková H., Růžička E. Deep brain stimulation in acute management of status dystonicus. Mov Disord 2009; 11;24(15):2291-2292
6.Jech R., Klempíř J., Vymazal J., Židovská J., Klempířová O., Růžička E., Roth J. Variation of selective gray and white matter atrophy in Huntington's disease. Mov Disord 2007; 22(12):1783-1789
7.Jech R., Růžička E., Urgošík D., Serranová T., Volfová M., Nováková O., Roth J., Dušek P., Mečíř P. Deep brain stimulation of the subthalamic nucleus affects resting EEG and visual evoked potentials in Parkinson´s disease Clin Neurophysiol. 2006;117(5):1017-1028
8.Jech R., Dušek P., Wackermann J., Vymazal J. Cumulative BOLD signal changes support the "time accumulator" hypothesis. Neuroreport 2005;16(13):1467-1471
9.Jech R., Urgošík D., Tintěra J., Nebuželský A., Krásenský J., Liščák R., Roth J., Růžička E. Functional magnetic resonance imaging during deep brain stimulation: A pilot study in four patients with Parkinson´s disease. Movement Disorders 2001;16(4):1126-1132

Pregraduate students:
Graduate´s nameFromToTheme
Nolan Walker20022004Functional imaging of active and passive movements
Grégory OpertoIII/2004VII/2004Software for motion detection during event-related fMRI
Luca Di Gesaro I/20112004Clinical effects of deep brain stimulation

Current list of the supervisor´s PG students:
Student´s name Study duration and form Theme Note.
regular combined
Petra Havránková, M.D. 2003-2006 2006- Kortikální mechanismy fokálních dystonií  
Petr Dušek, M.D. 2003-2006 2006- Percepce času  
Robert Bartoš, M.D.   2005-2010 fMRI ve stereonavigaci primární motorické oblasti  
Tereza Serranová, M.D. 2003-2006 2006- Non-motorické účinky DBS - afektivita  
Filip Růžička, M.D. 2003-2006 2006- Non-motorické účinky DBS - tloustnutí  
Antonín Srp, M.D. 2009-   Spontánní fluktuace BOLD signálu u extrapyramidových onemocnění  
Anna Fečíková, M.D. 2010-   Kortikální excitabilita u dystonických syndromů - efekt DBS  
Mgr. Tomáš Sieger 2009-   Neuronální aktivita bazálních ganglií  
Mgr. Štefan Hoľiga 2010-   Detekce pohybu pomocí kompatibilních rukavic pro účely fMRI  

List of salient publications: produced within the PGS programme at the Department of Neurology:
1.Dušek P., Jech R., Wackermann J., Vymazal J. Effects of dopaminergic therapy on time perception in Parkinson's disease: An event-related fMRI study. Fechner Day 2005, Proceedings of the 21st Annual Meeting of the International Society for Psychophysics, 77-82
2.Bartoš R., Jech R., Vymazal J., Cihlář F., Hejčl A., Sameš M. Spolehlivost lokalizace primární motorické oblasti pomocí funkční magnetické rezonance. Čes Slov Neurol Neurochir 2006;69/102(3):189-194
3.Ulmanová O., Homann C. N., Ulman R., Jech R., Čapek V., Klempíř J., Růžička E. Tremor magnitude: a single index to assess writing and drawing in essential tremor. Parkinsonism Relat Disord 2007;13(4):250-253
4.Nováková L., Růžička E., Jech R., Serranová T., Dušek P., Urgošík D. Increase in body weight is an non-motor side effect of deep brain stimulatin of the subthalamic nucleus in Parkinson's disease. Neuroendocrinology Letters 2007;28(1):21-25
5.Jiroutek P., Růžička E., Roth J., Jech R. Slowly progressive voluntary-automatic dissociation of facial movements (Foix-Chavany-Marie syndrome). Neuro Endocrinol Lett 2007;15;28(2):137-140
6.Vymazal J., Klempíř J., Jech R., Židovská J., Syka M., Růžička E., Roth J. MR Relaxometry in Huntington's Disease: Correlation between Imaging, Genetic and Clinical Parameters. J Neurol Sci. 2007 Dec 15;263(1-2):20-5
7.Zumrová A., Mušová Z., Havlovicová M., Schwabová J., Jech R., Hlavová E. Syndrom fragilního chromozómu X s tremorem/ataxií ,FXTAS): pilotní studie na souboru pacientů nejasné etiologie. Cesk Slov Neurol N 2007;70/103(5):558-561
8.Serranová T, Valls-Solé J, Mu?oz E, Genís D, Jech R, Seeman P. Abnormal corticospinal tract modulation of the soleus H reflex in patients with pure spastic paraparesis. Neurosci Lett. 2008 May 23;437(1):15-9
9.Havránková P., Jech R., Roth J., Urgošík D., Růžička E. Beneficial effect of deep brain stimulation of GPi in a Patient with dystonia-deafness phenotype. Mov Disord. 2009 Feb 15;24(3):465-6
10.Bartoš R., Jech R., Vymazal J., Petrovický P., Hejčl A., Zolal A., Sameš M. Validity of primary motor area localization with fMRI versus electric cortical stimulation. Acta Neurochir (Wien). 2009;151(9):1071-80
11.Havránková P, Jech R, Walker ND, Operto G, Tauchmanová J, Vymazal J, Dušek P, Hromčík M, Růžička E. Repetitive TMS of the somatosensory cortex improves writer's cramp and enhances cortical activity. Neuro Endocrinol Lett. 2010;31(1):73-86
12.Anders M, Dvořáková J, Rathováa L, Havránková P, Pelcova P, Vaněčková M, Jech R, Holcát M, Seidl Z, Raboch J. Efficacy of repetitive transcranial magnetic stimulation for the treatment of refractory chronic tinnitus: A randomized, placebo controlled study. Neuro Endocrinol Lett. 2010;31(2):238-249
13.Dušek P, Bušková J, Růžička E, Majerová V, Srp A, Jech R, Roth J, Šonka K. Effects of ropinirole prolonged-release on sleep disturbances and daytime sleepiness in Parkinson disease. Clin Neuropharmacol. 2010 Jul;33(4):186-90
14.Keller J., Vymazal J., Ridzoň P., Rusina R., Kulišťák P., Malíková H., Rulseh A.M., Keller O., Jech R. Quantitative Brain MR Imaging in Amyotrophic Lateral Sclerosis. MAGMA 2010

David Kemlink, M.D., Ph.D.
Department of Neurology, Centre for Sleep and Waking Disorders
Kateřinská 30, Praha 2, 128 21
Tel.: 224 96 55 18
E-mail: kemlink@volny.cz

General PGS themes:
  • Restless leg syndrome - clinical and genetic aspects
  • Neurophysiological methods for sleep testing - application of polysomnography and actigraphy
  • Genetic association and linkage studies - practical uses of statistical genetics in neurological disorders

Annotation of themes:
Research is mainly concerned with sleep disorder studies at the Centre for Sleep and Waking Disorders, in particular: the restless leg syndrome. Work in this field is centered on the clinical aspects of the syndrome, making good use of especially the monitoring capacity of the sleep laboratory. In cooperation with counterparts in Munich, basic research is in progress of its genetic mechanisms with the aid of large capacity platforms. The association study basic procedures for the detection and verification of the effect of human genome polymorphism can also be applied to other multifactorial diseases with significant genetic components; as for sleep disorders, research into narcolepsy is now in progress.

The supervisor´s three main theme-related publications:
1.Schormair B & Kemlink D, Roeske D, Eckstein G, Xiong L, Lichtner P, Ripke S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Högl B, Frauscher B, Gschliesser V, Poewe W, Peglau I, Vodicka P, Vávrová J, Sonka K, Nevsimalova S, Montplaisir J, Turecki G, Rouleau G, Gieger C, Illig T, Wichmann HE, Holsboer F, Müller-Myhsok B, Meitinger T, Winkelmann J. Nat Genet. 2008 Aug;40(8):946-8
2.Kemlink D, Plazzi G, Vetrugno R, Provini F, Polo O, Stiasny-Kolster K, Oertel W, Nevsimalova S, Sonka K, Högl B, Frauscher B, Hadjigeorgiou GM, Pramstaller PP, Lichtner P, Meitinger T, Müller-Myshok B, Winkelmann J, Montagna P. Suggestive evidence for linkage for restless legs syndrome on chromosome 19p13. Neurogenetics. 2008 May;9(2):75-82
3.Replication of restless legs syndrome loci in three European populations.Kemlink D, Polo O, Frauscher B, Gschliesser V, Högl B, Poewe W, Vodicka P, Vavrova J, Sonka K, Nevsimalova S, Schormair B, Lichtner P, Silander K, Peltonen L, Gieger C, Wichmann HE, Zimprich A, Roeske D, Müller-Myhsok B, Meitinger T, Winkelmann J. J Med Genet. 2009 May;46(5):315-8

Current list of the supervisor´s PG students:
Student´s name Study duration and form Theme Note.
regular combined
MUDr. Jana Vávrová 2008-   Genetické aspekty syndromu neklidných nohou  
MUDr. Zuzana Šrůtková 2010-   Komorbidity hypersomnií a poruch hybnosti ve spánku  

Tomas Kalincik, MD, PhD.
Department of Neurology and Center of Clinical Neuroscience
Kateřinská 30, Praha 2, 128 21
Tel.: +420 224 96 65 15
E-mail: tomas.kalincik@unimelb.edu.au

General PGS themes:
  • Multiple sclerosis: prediction and prognosis, neuropsychology, pharmacoeconomy and genetics)

Annotation of themes:
The focus of the research is to investigate clinical and paraclinical predictors of course of multiple sclerosis and the efficacy of treatment. Other researched aspects of multiple sclerosis comprise: efficacy and safety of combined immunomodulatory and immunosuppressive therapy, osteoporosis, immunology, genetics, pharmacoeconomics and neurophysiology. Training in biostatistics and research methods is integrated in the research projects.

The supervisor's three main theme-related publications:
1.Kalincik T, Vaneckova M, Tyblova M, Krasensky J, Seidl Z, Havrdova E, Horakova D (2012) Volumetric MRI markers and predictors of disease activity in early multiple sclerosis: a longitudinal cohort study. PLoS One 7(11):e50101
2.Horakova D*, Kalincik T*, Dolezal O, Krasensky J, Vaneckova M, Seidl Z, Havrdova E (2012) Early predictors of non-response to interferon in multiple sclerosis. Acta Neurol Scand 126(6):390-7
3.Kalincik T*, Horakova D*, Dolezal O, Krasensky J, Vaneckova M, Seidl Z, Havrdova E (2012) Interferon, azathioprine and corticosteroids in multiple sclerosis: 6-year follow-up of the ASA cohort. Clin Neurol Neurosur 114:940-6

Current list of the supervisor´s PG students:
Student´s name Study duration and form Theme Note.
regular combined
MUDr. Veronika Tichá   2009- Combined therapy for multiple sclerosis  
MUDr. Michaela Týblová   2008- Osteoporosis in multiple sclerosis  
Mgr. Jana Blahová-Dušánková   2005- Neuropsychology of multiple sclerosis. Cost of multiple sclerosis  
MUDr. Petra Nytrová 2010-   Biomarkers in neuromyelitis optica  
MUDr. Pavla Zborníková 2010-   Gene expression and response to immunomodulatory treatment in multiple sclerosis  
MUDr. Veronika Majerová   2008- Non-motor signs of the disorders of basal ganglia  

List of salient publications: produced within the PGS programme at the Department of Neurology:
1.Blahova Dusankova J*, Kalincik T*, Havrdova E, Benedict RHB (2012) Cross Cultural Validation of the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) and the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS). Clin Neuropsychol 26:1186-1200
2.Ticha V*, Kalincik T*, Havrdova E (2012) Interferon beta or azathioprine as add-on therapies in patients with active multiple sclerosis. Neurol Res 34(10):923-930
3.Zbornikova P, Kralik L, Lelkova P, Kalincik T, Havrdova E, Martasek P (2012) Microsatellite polymorphism in heme oxygenase 1 gene promoter in multiple sclerosis. Folia Biologica 58(2):69-74
4.Horakova D*, Kalincik T*, Blahova Dusankova J, Dolezal O (2012) Clinical correlates of grey matter pathology in multiple sclerosis. BMC Neurol 12:10
5.Blahova Dusankova J, Kalincik T, Dolezal T, Kobelt G, Havrdova E (2012) Cost of multiple sclerosis in the Czech Republic: the COMS study. Mult Scler J 18(5):662-8
6.Majerová V, Kalinčík T, Laczó J, Vyhnálek M, Hort J, Bojar M, Růžička E, Roth J (2012) Disturbance of real space navigation in moderately advanced but not in early Huntington's disease. J Neurol Sci 312(1-2):86-91


Hana Brožová,M.D., Ph.D.
Department of Neurology and Center of Clinical Neuroscience
Kateřinská 30, Praha 2, 128 21
Telefon: 224 96 55 39
E-mail: hana.brozova@lf1.cuni.cz


Iva Příhodová,M.D., Ph.D.
Department of Neurology and Center of Clinical Neuroscience
Kateřinská 30, Praha 2, 128 21
Telefon: 224 96 55 32
E-mail: iva.prihodova@lf1.cuni.cz

General PGS themes:
  • Sleep disorders in childhood and their health consequences
  • Abnormal movements related to sleep
  • Sleep disorders in child neuropsychiatric disorders

Annotation of themes:
Research topics are aimed at child sleep disorders which can influence the quality of life (abnormal movements related to sleep, obstructive sleep apnoea, parasomnias). Sleep assessment can be based on evaluation of polysomnographic characteristics including sleep mictrostructure. Questionnaires and actigraphy represent other possibilities of sleep investigation.
Another topic is an incidence of sleep disorders in child neuropsychiatric disorders (attention deficit/hyperactivity disorder, Tourette syndrome), possible mutual relationship and impact on clinical symptomatology.

The supervisor's three main theme-related publications:
1.Prihodova I, Paclt I, Kemlink D, Skibova J, Ptacek R, Nevsimalova S. Sleep disorders and daytime sleepiness in children with attention-deficit/hyperactivity disorder: a two-night polysomnographic study with a multiple sleep latency test. Sleep Med 2010;11:922-8
2.Prihodova I, Sonka K, Kemlink D, Volna J, Nevsimalova S. Arousals in nocturnal groaning. Sleep Med 2009; 9:1051-1055
3.Stepanova I, Nevsimalova S, Hanusova J. Rhythmic  movement disorder in sleep persisting into childhood and adulthood. Sleep 2005; 28: 851-857

Current list of the supervisor´s PG students:
Student´s name Study duration and form Theme Note.
regular combined
MUDr. Lenka Plchová 2010-   Porucha chování v REM spánku  


Jiří Klempíř,M.D., Ph.D.
Department of Neurology and Center of Clinical Neuroscience
Kateřinská 30, Praha 2, 128 21
Tel.: 224965539, 224965078
E-mail: jiri.klempir@seznam.cz

General PGS themes::

Annotation of themes:

The supervisor's three main theme-related publications:
1.Klempíř J, Židovská J, Štochl J, Kebrlová V, Uhrová T, Roth J. The number of CAG repeats within the normal allele does not influence the age of onset in Huntington's disease. Mov Disord. 2011;26:125-9. IF:4,014
2.Klempíř J, Klempířová O., Roth J. Influence of emotional instability on behavioral disorders in DYT11. Mov Disord. 2010;25:791-2. IF:4,014
3.Klempíř J, Klempířová O, Štochl J, Špačková N, Roth J. The relationship between impairment of voluntary movements and cognitive impairment in Huntington's disease. J Neurol. 2009;256:1629-33. IF:2,536
4.Vymazal J, Klempíř J, Jech J, Syka M, Růžička E, Roth J. MR Relaxometry in Huntington´s Disease: Correlation between Imaging, Genetic and Clinical Parameters. J Neurol Sciences, 2007; 263:20-5, IF:2,366
5.Jech R, Klempíř J, Židovská J, Vymazal J, Růžička E, Klempířová O, Roth J. Variations of selective gray and white matter atrophy in Huntington’s disease. Mov Dis, 2007; 22:1783-9. IF:2,9

Jitka Bušková,M.D., Ph.D.
Department of Neurology and Center of Clinical Neuroscience
Kateřinská 30, Praha 2, 128 21
Tel.: 224965539, 224965078
E-mail: jiri.klempir@seznam.cz

General PGS themes::

Annotation of themes:

The supervisor's three main theme-related publications:
1.Bušková J, Piško J, Pastorek L, Šonka K. The course and character of sleepwalking in adulthood: a clinical and polysomnographic study. Behav Sleep Med 2013, accepted 8/2013. IF= 1.125
2.Bušková J, Piško J, Dostálová S, Růžička E, Šonka K. Incomplete sleep paralysis as the first symptom of narcolepsy. Sleep Med 2013;14:919-21. IF=3.487
3.Bušková J, Vorlová T, Piško J, Šonka K. Severe sleep-related movement disorder induced by sertraline. Sleep Med 2012;13:769-770. IF=3.487
4.Bušková J, Klempíř J, Majerová V, Picmausová J, Šonka K, Jech R, Roth J, Růžička E. Sleep disturbances in untreated Parkinson´s disease. J Neurol 2011;259:2254-9. IF= 2.903
5.Bušková J, Klaschka J, Šonka K, Nevšímalová S. Olfactory dysfunction in narcolepsy with and without cataplexy. Sleep Med 2010;11:558-561. IF=3.699
6.Morrison I, Bušková J, Nevšímalová S, Douglas NJ, Riha RL. Diagnosing narcolepsy with cataplexy on history alone: challenging the International Classification of Sleep Disorders (ICSD-2) criteria. Eur J Neurol 2011; 18:1017-20. IF=2.510
7.Bušková J. The neurobiological basis of hallucinations. Hallucinations – types, stages and treatments in Nova biomedical, Neuroscience research progress. 2011; Chapter 13, Pages: 219-223.

Aktualizováno: 30.11. 2013